PEGASYS

LOE Approaching

peginterferon alfa-2a

Adienne Pharma and Biotech
BLASUBCUTANEOUSSYRINGE
Approved
Oct 2002
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20

Mechanism of Action

alfa-2a is an inducer of the innate antiviral immune response [see ] .

Pharmacologic Class:

Interferon alpha

Indications (12)

compensated liver diseasecompensated liver disease if there are contraindicationssignificant intolerance to other HCV antiviral drugsolder with CHCHBeAg-negative CHB infectionevidence of viral replicationliver inflammationHBeAg-positive CHB in non-cirrhotic pediatric patients 3 years of ageolder with evidence of viral replicationelevations in serum alanine aminotransferase (ALT)hepatitis CHepatitis B

Clinical Trials (5)

NCT02573025Phase 1Completed

A Bioequivalence Study of Pegylated Interferon Alfa-2a (PEG-IFN Alfa-2a) Benzyl Alcohol (BA)-Free Formulation Versus PEG-IFN Alfa-2a (Pegasys) Following Subcutaneous Administration

Started Sep 2015
277 enrolled
Healthy Volunteers
NCT02201407N/ACompleted

An Observational Study in Participants With Chronic Hepatitis B (CHB) Receiving Therapy With Peginterferon Alfa-2a 40 Kilodaltons (kD) (PEGASYS) - The PRO B Study

Started Dec 2014
50 enrolled
Hepatitis B, Chronic
NCT01679834N/ACompleted

An Observational Study of Pegasys in Dual- or Triple-Therapy in Patients With Chronic Hepatitis C

Started Nov 2014
7,500 enrolled
Hepatitis C, Chronic
NCT02118597N/ATerminated

An Observational Study Examining the Use of Triple Combination Therapy With Boceprevir, Peginterferon Alfa-2a and Ribavirin in the Re-Treatment of Chronic Hepatitis C Patients

Started May 2014
19 enrolled
Hepatitis C, Chronic
NCT01855997N/ACompleted

A Study to Collect Blood Biomarker Samples From Participants With Chronic Hepatitis B (CHB) Who Received Treatment With Pegasys (Peginterferon Alfa-2a) ± Nucleoside/Nucleotide Analogue

Started Aug 2013
1,669 enrolled
Hepatitis B, Chronic
Company
AP
Adienne Pharma and Biotech
Italy - Caponago
5 open jobs
External Resources
DailyMed
Full prescribing information
FDA Drugs@FDA
FDA approval history
RxNorm
Drug nomenclature & identifiers