NDAOPHTHALMICSOLUTION/DROPS
Approved
Jul 1969
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
PAREDRINE (hydroxyamphetamine hydrobromide) by PhotoPharmics is clinical pharmacology paremyd solution combines the effects of the adrenergic agent, hydroxyamphetamine hydrobromide, and the anticholinergic agent, tropicamide. First approved in 1969.
Drug data last refreshed 16h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
PAREDRINE (hydroxyamphetamine hydrobromide) is a topical ophthalmic solution combining an indirectly-acting sympathomimetic agent with an anticholinergic agent to produce mydriasis (pupil dilation) and facilitate ophthalmoscopy. It works by releasing endogenous norepinephrine from adrenergic nerve terminals while blocking cholinergic responses in the iris and ciliary muscle. The combination produces rapid onset (15 minutes) with maximum effect within 60 minutes, lasting 3–8 hours.
LOE Approaching
Established mature product approaching loss of exclusivity with minimal recent investment signals; commercial team likely focused on defending market share against generic entry and maintaining existing customer relationships in a competitive (~30 pressure index) specialty ophthalmology segment.
Mechanism of Action
CLINICAL PHARMACOLOGY PAREMYD Solution combines the effects of the adrenergic agent, hydroxyamphetamine hydrobromide, and the anticholinergic agent, tropicamide. Hydroxyamphetamine hydrobromide is an indirectly-acting sympathomimetic agent which, when applied topically to the eye, causes the…
Indications
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.