Mechanism of Action
Pegvaliase-pqpz is a PEGylated phenylalanine ammonia lyase (PAL) enzyme that converts phenylalanine to ammonia and trans -cinnamic acid. It substitutes for the deficient phenylalanine hydroxylase (PAH) enzyme activity in patients with PKU and reduces blood phenylalanine concentrations.
Phenylalanine Metabolizing Enzyme
Clinical Trials (5)
Rapid Drug Desensitization Study in Adults Experiencing Hypersensitivity Reactions to Palynziq
A Long Term, Post-marketing Study of Immune Response in Patients Receiving Palynziq Treatment for PKU (PALisade)
A Global, Multicenter Study to Assess Maternal, Fetal and Infant Outcomes of Exposure to Palynziq® (Pegvaliase) During Pregnancy and Breastfeeding
A Long-term, Post-marketing Safety Study of Palynziq in Patients With PKU (PALace)
Preliminary Study of Brain Effects of Palynziq-Related Changes in Phenylalanine in Individuals With PKU