NDAORAL-21TABLET
Approved
Mar 1966
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
OVULEN-21 (ethynodiol diacetate; mestranol) by Pfizer is clinical pharmacology combination oral contraceptives act primarily by suppression of gonadotropins. Approved for pregnancy in women. First approved in 1966.
Drug data last refreshed 23h ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
OVULEN-21 is a combination oral contraceptive containing ethynodiol diacetate and mestranol, approved in 1966. It prevents pregnancy primarily by suppressing gonadotropins to inhibit ovulation, with secondary effects on cervical mucus and endometrial changes that reduce fertilization and implantation likelihood.
LOE Approaching
This legacy product faces imminent patent expiration in a highly competitive, mature oral contraceptive market dominated by newer formulations; support teams are likely consolidating.
Mechanism of Action
CLINICAL PHARMACOLOGY Combination oral contraceptives act primarily by suppression of gonadotropins. Although the primary mechanism of this action is inhibition of ovulation, other alterations in the genital tract, including changes in the cervical mucus (which increase the difficulty of sperm…
Indications (1)
Career Relevance
With zero linked job openings and LOE Approaching status, career growth on OVULEN-21 is severely constrained; opportunities exist only in defensive commercial roles (payer relations, managed markets, generics liaison) or pharmacovigilance support. This represents a legacy product stewarding role rather than a growth career accelerator at Pfizer.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.