OTEZLA
PeakNDAORALTABLET
Approved
Sep 2014
Lifecycle
Peak
Competitive Pressure
30/100
Clinical Trials
7
Data completeness
6/8 — Strong
OTEZLA by Bristol Myers Squibb is 4 (pde4) specific for cyclic adenosine monophosphate (camp). Approved for older, weighing at least 20 kg with active psoriatic arthritis, weighing at least 50 kg with active psoriatic arthritis and 3 more indications. First approved in 2014.
Drug data last refreshed 22h ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
OTEZLA (apremilast) is an oral phosphodiesterase-4 (PDE4) inhibitor approved by the FDA in September 2014 for treating active psoriatic arthritis and moderate to severe plaque psoriasis in patients weighing at least 20 kg. The drug works by inhibiting PDE4, which increases intracellular cyclic adenosine monophosphate (cAMP) levels, though the precise therapeutic mechanism remains incompletely understood. As an oral small-molecule immunomodulator, it offers a non-biologic alternative to TNF inhibitors and other systemic therapies for inflammatory skin and joint conditions.
$0.9BPart D
Mechanism of Action
4 (PDE4) specific for cyclic adenosine monophosphate (cAMP). PDE4 inhibition results in increased intracellular cAMP levels. The specific mechanism(s) by which apremilast exerts its therapeutic action is not well defined.
Indications (6)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.