OTEZLA
PeakNDAORALTABLET
Approved
Sep 2014
Lifecycle
Peak
Competitive Pressure
30/100
Clinical Trials
7
Data completeness
6/8 — Strong
OTEZLA by Bristol Myers Squibb is 4 (pde4) specific for cyclic adenosine monophosphate (camp). Approved for older, weighing at least 20 kg with active psoriatic arthritis, weighing at least 50 kg with active psoriatic arthritis and 3 more indications. First approved in 2014.
Drug data last refreshed 7h ago · AI intelligence enriched 6d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
OTEZLA (apremilast) is an oral small-molecule PDE4 inhibitor approved for psoriatic arthritis and moderate-to-severe plaque psoriasis in patients weighing at least 20 kg. It works by inhibiting phosphodiesterase 4 (PDE4), increasing intracellular cAMP levels, though the precise therapeutic mechanism remains incompletely defined.
$0.877BPart D
PeakStable
At peak lifecycle with $877M Part D spending, OTEZLA supports a mature commercial organization but faces erosion from competing mechanisms and biosimilar-ready competitors.
Mechanism of Action
4 (PDE4) specific for cyclic adenosine monophosphate (cAMP). PDE4 inhibition results in increased intracellular cAMP levels. The specific mechanism(s) by which apremilast exerts its therapeutic action is not well defined.
Indications (6)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.