NDAORALCAPSULE
Approved
Dec 2020
Lifecycle
Peak
Competitive Pressure
0/100
Mechanism of Action
activity. Plasma kallikrein is a protease that cleaves high-molecular-weight kininogen (HMWK) to generate cleaved HMWK (cHMWK) and bradykinin, a potent vasodilator that increases vascular permeability resulting in swelling and pain associated with HAE. In patients with HAE due to C1-inhibitor…
Loss of Exclusivity
LOE Date
May 1, 2040
172 months away
Patent Expiry
May 1, 2040
Exclusivity Expiry
Jun 3, 2028