NDAORALSUSPENSION
Approved
Dec 2012
Lifecycle
Peak
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
4/8 — Partial
ONFI (clobazam) by Lundbeck is cytochrome p450 2d6 inhibitors [moa]. First approved in 2012.
Drug data last refreshed 3h ago · AI intelligence enriched 6d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ONFI (clobazam) is an oral benzodiazepine suspension approved in 2012 that acts as a cytochrome P450 2D6 inhibitor. It is indicated for adjunctive treatment of seizures, primarily in pediatric and adult epilepsy populations. The drug modulates GABA receptor activity to reduce seizure frequency and severity.
$0.032BPart D
PeakAt peak lifecycle stage with $32M in Part D spending; stable mature product with established market position supports core commercial and medical affairs roles.
Mechanism of Action
Cytochrome P450 2D6 Inhibitors
Pharmacologic Class:
Benzodiazepine
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
Single-arm, Multi-center Study Evaluating the Acceptance and Feasibility of a Digital Remote Monitoring Tool Configured for Patients With ATTR-CM: ACO-Monitor
Started Aug 2026
60 enrolled
Transthyretin Amyloid Cardiomyopathy (ATTR-CM)
Confirmatory Study of Govorestat in CMT-SORD
Started May 2026
0Charcot-Marie-Tooth Disease With Sorbitol Dehydrogenase Deficiency (CMT-SORD)
A Study in Pediatric Participants Aged ≥2 to <12 Years With a Suspected or Confirmed Bacterial Infection or Receiving Prophylaxis Antibiotics
Started Apr 2026
20 enrolled
Urinary Tract Infections
Confirmatory Clinical Study in Active Ulcerative Colitis
Started Apr 2026
204 enrolled
Colitis, Ulcerative
Evaluation of a Wearable PAP Device in a Tethered Configuration for the Treatment of Obstructive Sleep Apnoea.
Started Mar 2026
15 enrolled
OSA - Obstructive Sleep Apnea
Worked on ONFI at Lundbeck? Share your interview experience or compensation data (+7 days Pro)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.