BLASUBCUTANEOUSINJECTABLE1 Generic Approved
Approved
Jun 2019
Lifecycle
Peak
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
4/8 — Partial
NUCALA (mepolizumab) by GSK is interleukin-5 antagonists [moa]. Approved for interleukin-5 antagonist [epc]. First approved in 2019.
Drug data last refreshed 3d ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
NUCALA (mepolizumab) is a monoclonal antibody that blocks interleukin-5 (IL-5), a key cytokine driving eosinophil production and activation. It is approved for severe asthma, hypereosinophilic syndrome, and eosinophilic granulomatosis with polyangiitis. The drug is administered as a subcutaneous injection and represents a precision medicine approach for eosinophil-driven inflammatory diseases.
Peak
NUCALA is in peak commercial stage with $261M in spending, indicating sustained market investment and stable team structures supporting the franchise.
Mechanism of Action
Interleukin-5 Antagonists
Pharmacologic Class:
Interleukin-5 Antagonist
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
REIMAGINE - Real World EvaluatIon of Mepolizumab in Severe Asthma achievinG on Treatment clinIcal remissioN, a prospEctive Study
Started Mar 2024
336 enrolled
Asthma
Biomarkers of Response to Mepolizumab Treatment in Patients With Nasal Polyps With or Without Bronchial Asthma
Started Feb 2024
57 enrolled
Chronic Rhinosinusitis With Nasal PolypsAsthma
Immunological Basis for Mepolizumab Activity in COPD
Started Apr 2023
30 enrolled
COPD
Symptoms Control and adhErenCe Assessment During Treatment With MepolizUmab New pREfilled Devices
Started Mar 2023
20 enrolled
Asthma
Mepolizumab and Physical Activity in Severe Asthma
Started Feb 2023
62 enrolled
AsthmaAsthma; Eosinophilic
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.