NDAORALSUSPENSION
Approved
Oct 2006
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
3/8 — Basic
NOXAFIL (posaconazole) by Merck & Co. is [see clinical pharmacology (12. First approved in 2006.
Drug data last refreshed 15h ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
NOXAFIL (posaconazole) is an oral azole antifungal suspension approved in 2006 for treatment of invasive fungal infections including aspergillosis and invasive candidiasis. It works by inhibiting fungal cell wall synthesis through azole mechanism of action, making it suitable for immunocompromised patients who cannot tolerate IV formulations.
LOE Approaching
Product approaching loss of exclusivity with competitive pressure score of 30, signaling potential team contraction and shift toward generic transition planning.
Mechanism of Action
[see Clinical Pharmacology (12.4)] .
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
Posaconazole (MK-5592) Intravenous and Oral in Children (<2 Years) With Invasive Fungal Infection (MK-5592-127)
Started Feb 2022
40 enrolled
Invasive Fungal Infection
Pharmacokinetic of Posaconazole in Critically Ill Patients
Started Feb 2021
10 enrolled
Therapeutic Drug MonitoringCritical Illness
Posaconazole (MK-5592) Intravenous and Oral in Children With Invasive Aspergillosis (IA) (MK-5592-104)
Started Jul 2020
31 enrolled
Invasive Aspergillosis
Posaconazole Prophylaxis for CAPA Prevention in Critically-Ill Patients
Started Mar 2020
249 enrolled
COVID-19 Respiratory InfectionAspergillosis
Posaconazole Pharmacokinetics in Patients Receiving Chemotherapy or Stem Cell Transplants
Started Aug 2019
100 enrolled
PosaconazolePharmacokineticsInvasive Candidiases+4 more
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.