NDAORALTABLET
Approved
Feb 2010
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
3/8 — Basic
NORVIR (ritonavir) by AbbVie is hiv protease inhibitors [moa]. First approved in 2010.
Drug data last refreshed 15h ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
NORVIR (ritonavir) is an oral HIV protease inhibitor approved by the FDA in February 2010 for treatment of HIV infection and AIDS. It works by inhibiting HIV protease, an enzyme essential for viral replication, and also acts as a potent CYP3A inhibitor commonly used to boost the bioavailability of other antiretroviral agents. Patients with HIV infection use ritonavir either as a treatment component or as a pharmacokinetic booster in combination antiretroviral regimens.
LOE Approaching
With LOE approaching and moderate competitive pressure (30%), the NORVIR brand team is likely transitioning from growth initiatives to retention and lifecycle management strategies.
Mechanism of Action
HIV Protease Inhibitors
Pharmacologic Class:
Cytochrome P450 3A Inhibitor
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (20)
Drug Interactions Between Lopinavir/Ritonavir and Oral or Patch Contraceptives in HIV Infected Women
32 enrolled
HIV InfectionsPregnancy
The Safety and Effectiveness of Ritonavir in the Treatment of HIV-Related Kaposi's Sarcoma
Sarcoma, KaposiHIV Infections
A Study of Ritonavir (an Anti-HIV Drug) in HIV-Positive Infants and Children
60 enrolled
HIV Infections
Safety of AMD070 When Administered Alone or Boosted With Low-Dose Ritonavir in HIV Uninfected Men
44 enrolled
HIV Infections
Fortovase (Saquinavir) Given With Low-Dose Ritonavir, Zidovudine, and Lamivudine to HIV-Positive Pregnant Women During and After Pregnancy and to Their Newborns
24 enrolled
HIV InfectionsPregnancy
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.