NDASUBLINGUALSPRAY, METERED
Approved
Oct 1985
Lifecycle
LOE Approaching
Competitive Pressure
15/100
Clinical Trials
6
Data completeness
5/8 — Partial
NITROLINGUAL PUMPSPRAY (nitroglycerin) by Pfizer is (no), which activates guanylate cyclase, resulting in an increase of guanosine 3',5'-monophosphate (cyclic gmp) in smooth muscle and other tissues. Approved for angina pectoris, coronary artery disease. First approved in 1985.
Drug data last refreshed 23h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
NITROLINGUAL PUMPSPRAY is a sublingual metered spray formulation of nitroglycerin, a nitrate vasodilator approved in 1985 for acute relief of angina pectoris and coronary artery disease. It works by releasing nitric oxide (NO), which activates guanylate cyclase to increase cyclic GMP in smooth muscle, leading to vasodilation of coronary arteries and peripheral vessels. This mechanism reduces cardiac preload and afterload while improving coronary blood flow.
LOE Approaching2.9 years to LOE
Product is in LOE-approaching phase with moderate competitive pressure (15 competitors), indicating a transitional stage requiring defense strategies and potential team restructuring as generic entry nears.
Mechanism of Action
(NO), which activates guanylate cyclase, resulting in an increase of guanosine 3',5'-monophosphate (cyclic GMP) in smooth muscle and other tissues. This eventually leads to dephosphorylation of myosin light chains, which regulates the contractile state in smooth muscle and results in vasodilatation.
Pharmacologic Class:
Nitrate Vasodilator
Indications (2)
Worked on NITROLINGUAL PUMPSPRAY at Pfizer? Share your interview experience or compensation data (+7 days Pro)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.