NDASUBLINGUALAEROSOL
Approved
Oct 1985
Lifecycle
LOE Approaching
Competitive Pressure
15/100
Clinical Trials
6
Data completeness
6/8 — Strong
NITROLINGUAL (nitroglycerin) by Pfizer is (no), which activates guanylate cyclase, resulting in an increase of guanosine 3',5'-monophosphate (cyclic gmp) in smooth muscle and other tissues. Approved for coronary artery disease, heart failure. First approved in 1985.
Drug data last refreshed 19h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
NITROLINGUAL is a sublingual nitroglycerin aerosol approved in 1985 for acute relief and prevention of angina pectoris and other cardiovascular conditions. It works by releasing nitric oxide, which activates guanylate cyclase and increases cyclic GMP in smooth muscle, leading to vasodilatation and reduced cardiac workload. The drug treats a broad range of indications including coronary artery disease, heart failure, hypertension, and cerebral vasospasm.
$36KPart D
LOE ApproachingDeclining
2.9 years to LOEVery limited commercial opportunity; product is in late maturity with minimal market presence and low headcount requirements.
Mechanism of Action
(NO), which activates guanylate cyclase, resulting in an increase of guanosine 3',5'-monophosphate (cyclic GMP) in smooth muscle and other tissues. This eventually leads to dephosphorylation of myosin light chains, which regulates the contractile state in smooth muscle and results in vasodilatation.
Pharmacologic Class:
Nitrate Vasodilator
Indications (2)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.