NITROLINGUAL
Peaknitroglycerin
NDASUBLINGUALAEROSOL
Approved
Oct 1985
Lifecycle
Peak
Competitive Pressure
8/100
Clinical Trials
4
Mechanism of Action
(NO), which activates guanylate cyclase, resulting in an increase of guanosine 3',5'-monophosphate (cyclic GMP) in smooth muscle and other tissues. This eventually leads to dephosphorylation of myosin light chains, which regulates the contractile state in smooth muscle and results in vasodilatation.
Pharmacologic Class:
Nitrate Vasodilator
Clinical Trials (4)
A Study to Learn About How Safe Nitroglycerin is and How it Affects the Body When Taken Along With Nurandociguat in People With Coronary Artery Disease
Started Apr 2026
36 enrolled
Stable Coronary Artery Disease
Vericiguat Drug-drug Interaction With Nitroglycerin in Stable Coronary Artery Disease Patients
Started Nov 2015
36 enrolled
Coronary Artery Disease
Treatment of Suspected Cholelithiasis With Nitroglycerin
Started Oct 2014
62 enrolled
COLICBILIARY TRACT DISEASES
The Effect of Nitroglycerin on the Intrauterine Device (IUD) Insertion Experience in Nulliparous Women
Started Mar 2012
24 enrolled
ContraceptionPain
Loss of Exclusivity
LOE Date
Mar 12, 2029
36 months away
Patent Expiry
Mar 12, 2029
Patent Records (1)
| Patent # | Expiry | Type | Use Code |
|---|---|---|---|
| 7872049 | Mar 12, 2029 | Product | U-2223 |