NITROGLYCERIN

Post-LOE

nitroglycerin

ANDAINTRA-ANALOINTMENT
Approved
Dec 2025
Lifecycle
Post-LOE
Competitive Pressure
30/100
Clinical Trials
4

Mechanism of Action

(NO), which activates guanylate cyclase, resulting in an increase of guanosine 3',5'-monophosphate (cyclic GMP) in smooth muscle and other tissues. This leads to dephosphorylation of myosin light chains, which regulates the contractile state in smooth muscle and results in vasodilatation.

Pharmacologic Class:

Nitrate Vasodilator

Clinical Trials (4)

NCT07431294Phase 1Not Yet Recruiting

A Study to Learn About How Safe Nitroglycerin is and How it Affects the Body When Taken Along With Nurandociguat in People With Coronary Artery Disease

Started Apr 2026
36 enrolled
Stable Coronary Artery Disease
NCT02617550Phase 1Completed

Vericiguat Drug-drug Interaction With Nitroglycerin in Stable Coronary Artery Disease Patients

Started Nov 2015
36 enrolled
Coronary Artery Disease
NCT01715220Phase 2Unknown

Treatment of Suspected Cholelithiasis With Nitroglycerin

Started Oct 2014
62 enrolled
COLICBILIARY TRACT DISEASES
NCT01490073N/ACompleted

The Effect of Nitroglycerin on the Intrauterine Device (IUD) Insertion Experience in Nulliparous Women

Started Mar 2012
24 enrolled
ContraceptionPain