NITISINONE

Post-LOE

nitisinone

ANDAORALCAPSULE
Approved
May 2022
Lifecycle
Post-LOE
Competitive Pressure
30/100
Clinical Trials
3

Mechanism of Action

Hydroxyphenylpyruvate Dioxygenase Inhibitors

Pharmacologic Class:

4-Hydroxyphenyl-Pyruvate Dioxygenase Inhibitor

Clinical Trials (3)

NCT06227429N/AWithdrawn

A Non-interventional, Post-Marketing Study to Describe Outcome of Nitisinone Treatment in HT-1 Patients

Started Sep 2025
0
Hereditary Tyrosinemia, Type I
NCT03103568Phase 1Completed

A Study to Investigate the Potential Influence of Nitisinone on the Metabolism and the Transport of Other Drugs in Healthy Volunteers

Started Mar 2017
36 enrolled
Drug Drug Interaction
NCT02323529Phase 3Completed

Efficacy and Safety of Once Daily Dosing Compared to Twice Daily Dosing of Nitisinone in HT-1

Started Dec 2014
18 enrolled
Hereditary Tyrosinemia, Type I