NDAINJECTIONINJECTABLEPriority Review
Approved
Oct 1991
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
15
Data completeness
4/8 — Partial
Priority Review
NIPENT (pentostatin) by Pfizer is nucleic acid synthesis inhibitors [moa]. First approved in 1991.
Drug data last refreshed 5h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
NIPENT (pentostatin) is a nucleoside metabolic inhibitor administered by injection that works by inhibiting nucleic acid synthesis. It is indicated for hematologic malignancies, particularly hairy cell leukemia and other rare blood cancers. The drug depletes deoxyadenosine and deoxyadenosine triphosphate, leading to cell death in rapidly dividing lymphoid cells.
$0.092BPart D
LOE ApproachingWith LOE approaching and minimal commercial spending, this product supports a small, specialized team focused on maintaining market share in rare hematology rather than growth initiatives.
Mechanism of Action
Nucleic Acid Synthesis Inhibitors
Pharmacologic Class:
Nucleoside Metabolic Inhibitor
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (15)
Trial of Pentostatin Plus Cyclophosphamide With Ofatumumab (PCO) in Older Patients With Chronic Lymphocytic Leukemia
Started Sep 2011
47 enrolled
Chronic Lymphocytic Leukemia
Combination of Pentostatin, Bendamustine and Ofatumumab for Treatment of Chronic Lymphocytic Leukemia and Lymphoma
Started May 2011
10 enrolled
Chronic Lymphocytic LeukemiaB-Cell Non-Hodgkin's Lymphoma
A Trial of Extracorporeal Photopheresis, Pentostatin, and Total Body Irradiation in Patients Undergoing Reduced Intensity Allogeneic Stem Cell Transplantation for the Treatment of Malignancies
Started Jul 2006
14 enrolled
Hematologic Malignancies
Evaluation of the Safety and Efficacy of Nipent, Cytoxan, and Rituxan
Started Jun 2005
100 enrolled
Lymphoma
Pentostatin, Cyclophosphamide, and Rituximab in Treating Patients With Previously Untreated Chronic Lymphocytic Leukemia
Started May 2005
49 enrolled
LeukemiaLymphoma
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.