NIPENT

LOE ApproachingSM

pentostatin

NDAINJECTIONINJECTABLEPriority Review
Approved
Oct 1991
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
15

Mechanism of Action

Nucleic Acid Synthesis Inhibitors

Pharmacologic Class:

Nucleoside Metabolic Inhibitor

Clinical Trials (5)

NCT01681563Phase 2Completed

Trial of Pentostatin Plus Cyclophosphamide With Ofatumumab (PCO) in Older Patients With Chronic Lymphocytic Leukemia

Started Sep 2011
47 enrolled
Chronic Lymphocytic Leukemia
NCT01352312Phase 1Terminated

Combination of Pentostatin, Bendamustine and Ofatumumab for Treatment of Chronic Lymphocytic Leukemia and Lymphoma

Started May 2011
10 enrolled
Chronic Lymphocytic LeukemiaB-Cell Non-Hodgkin's Lymphoma
NCT00402714Phase 2Completed

A Trial of Extracorporeal Photopheresis, Pentostatin, and Total Body Irradiation in Patients Undergoing Reduced Intensity Allogeneic Stem Cell Transplantation for the Treatment of Malignancies

Started Jul 2006
14 enrolled
Hematologic Malignancies
NCT00496873Phase 2Completed

Evaluation of the Safety and Efficacy of Nipent, Cytoxan, and Rituxan

Started Jun 2005
100 enrolled
Lymphoma
NCT00541034Phase 2Completed

Pentostatin, Cyclophosphamide, and Rituximab in Treating Patients With Previously Untreated Chronic Lymphocytic Leukemia

Started May 2005
49 enrolled
LeukemiaLymphoma