NDAORALCAPSULEPriority Review
Approved
Dec 1988
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
2
Data completeness
3/8 — Basic
Priority Review
NIMOTOP (nimodipine) by R-Pharm US is mechanism of action nimodipine is a calcium channel blocker. First approved in 1988.
Drug data last refreshed 2h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
NIMOTOP (nimodipine) is an oral calcium channel blocker approved in 1988 for improving neurological outcomes following subarachnoid hemorrhage (SAH). It inhibits calcium ion transfer into vascular smooth muscle cells, with preferential activity in cerebral arteries due to its high lipophilicity and blood-brain barrier penetration. The precise mechanism of clinical benefit remains incompletely understood, though it demonstrably reduces severity of neurological deficits caused by cerebral vasospasm.
LOE Approaching
As a legacy product approaching loss of exclusivity with moderate competitive pressure (30), brand team focus is likely on cost optimization and market consolidation rather than growth.
Mechanism of Action
Mechanism of Action Nimodipine is a calcium channel blocker. The contractile processes of smooth muscle cells are dependent upon calcium ions, which enter these cells during depolarization as slow ionic transmembrane currents. Nimodipine inhibits calcium ion transfer into these cells and thus…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (2)
Acupuncture Combined With Nimodipine for Prevention of Post-stroke Dementia
Started Feb 2021
Randomized, Double-Blind, Placebo-Controlled Trial of Nimodipine for the Neurological Manifestations of HIV-1
36 enrolled
AIDS Dementia ComplexHIV Infections
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.