NDAORALTABLET
Approved
Dec 1959
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
NATURETIN-10 (bendroflumethiazide) by Bristol Myers Squibb is clinical pharmacology nadolol nadolol is a nonselective beta-adrenergic receptor blocking agent. Approved for hypertension, to lower blood pressure. First approved in 1959.
Drug data last refreshed 16h ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
NATURETIN-10 is bendroflumethiazide, a thiazide diuretic approved in 1959 for hypertension management. It lowers blood pressure by increasing sodium and chloride excretion in the renal tubule, reducing plasma volume and peripheral vascular resistance. The drug is an oral tablet formulation indicated as an antihypertensive agent.
LOE Approaching
Product is approaching loss of exclusivity with minimal commercial investment signals; brand support and field team size likely declining or consolidated with other legacy hypertension portfolios.
Mechanism of Action
CLINICAL PHARMACOLOGY Nadolol Nadolol is a nonselective beta-adrenergic receptor blocking agent. Clinical pharmacology studies have demonstrated beta-blocking activity by showing (1) reduction in heart rate and cardiac output at rest and on exercise, (2) reduction of systolic and diastolic blood…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.