NDAORALTABLET
Approved
Dec 1959
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
NATURETIN-10 (bendroflumethiazide) by Bristol Myers Squibb is clinical pharmacology nadolol nadolol is a nonselective beta-adrenergic receptor blocking agent. Approved for hypertension, to lower blood pressure. First approved in 1959.
Drug data last refreshed 9h ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
NATURETIN-10 (bendroflumethiazide) is a thiazide diuretic approved in 1959 for treating hypertension by lowering blood pressure through sodium and water excretion. The drug works by inhibiting sodium-chloride reabsorption in the distal renal tubule, reducing extracellular fluid volume and peripheral vascular resistance. It is indicated for hypertension management in patients requiring diuretic therapy.
LOE Approaching
Product approaching loss of exclusivity with minimal linked job openings and declining commercial relevance in a crowded hypertension market.
Mechanism of Action
CLINICAL PHARMACOLOGY Nadolol Nadolol is a nonselective beta-adrenergic receptor blocking agent. Clinical pharmacology studies have demonstrated beta-blocking activity by showing (1) reduction in heart rate and cardiac output at rest and on exercise, (2) reduction of systolic and diastolic blood…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.