NASCOBAL
LOE Approachingcyanocobalamin
NDANASALSPRAY, METERED
Approved
Jan 2005
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Mechanism of Action
12 can be converted to coenzyme B 12 in tissues, and as such is essential for conversion of methylmalonate to succinate and synthesis of methionine from homocysteine, a reaction which also requires folate. In the absence of coenzyme B 12 , tetrahydrofolate cannot be regenerated from its inactive…
Pharmacologic Class:
Vitamin B12
Clinical Trials (1)
Characterization of Cyanocobalamin in Healthy Voluteers After Intranasal and Intramuscual Administration
Started Feb 2011
16 enrolled
Focus: Bioavailability