NDANASALSPRAY, METERED
Approved
Jan 2005
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
2
Data completeness
4/8 — Partial
NASCOBAL (cyanocobalamin) by Accord Biopharma is 12 can be converted to coenzyme b 12 in tissues, and as such is essential for conversion of methylmalonate to succinate and synthesis of methionine from homocysteine, a reaction which also requires folate. First approved in 2005.
Drug data last refreshed 5h ago · AI intelligence enriched 1mo ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
NASCOBAL is a nasal spray formulation of cyanocobalamin (vitamin B12) approved in 2005 for treating B12 deficiency. It works by replenishing cobalamin levels, which are essential for methylmalonate conversion, methionine synthesis, and maintaining reduced sulfhydryl groups in enzyme systems critical for fat, carbohydrate, and protein metabolism. The nasal route provides an alternative to intramuscular injection for patients requiring B12 supplementation.
$0.008BPart D
LOE ApproachingMinimal Part D spending and claim volume indicate a niche product with limited commercial scale; expect small, stable regional teams focused on specialty pharmacy and patient adherence.
Mechanism of Action
12 can be converted to coenzyme B 12 in tissues, and as such is essential for conversion of methylmalonate to succinate and synthesis of methionine from homocysteine, a reaction which also requires folate. In the absence of coenzyme B 12 , tetrahydrofolate cannot be regenerated from its inactive…
Pharmacologic Class:
Vitamin B12
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (2)
Effect of Methylcobalamin and Cyanocobalamin Consumption on Vitamin B12 Nutritional Status
Started Sep 2023
54 enrolled
Vitamin B12 Nutritional Deficiency
Characterization of Cyanocobalamin in Healthy Voluteers After Intranasal and Intramuscual Administration
Started Feb 2011
16 enrolled
Focus: Bioavailability
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.