NDANASALSPRAY, METERED
Approved
Jan 2005
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
2
Data completeness
4/8 — Partial
NASCOBAL (cyanocobalamin) by Accord Biopharma is 12 can be converted to coenzyme b 12 in tissues, and as such is essential for conversion of methylmalonate to succinate and synthesis of methionine from homocysteine, a reaction which also requires folate. First approved in 2005.
Drug data last refreshed 3h ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
NASCOBAL is a metered nasal spray formulation of cyanocobalamin (vitamin B12) approved in 2005 for treating vitamin B12 deficiency and related cardiovascular conditions. The drug works by converting to coenzyme B12 in tissues, enabling critical metabolic reactions including methylmalonate conversion and methionine synthesis, which are essential for fat, carbohydrate, and protein metabolism. It addresses a niche but clinically important indication in patients who cannot absorb or tolerate oral or injectable B12 supplementation.
$8KPart D
LOE ApproachingMinimal commercial activity with only $8K in Part D spending (12 claims in 2023) indicates a very small, specialized market with limited team expansion opportunities.
Mechanism of Action
12 can be converted to coenzyme B 12 in tissues, and as such is essential for conversion of methylmalonate to succinate and synthesis of methionine from homocysteine, a reaction which also requires folate. In the absence of coenzyme B 12 , tetrahydrofolate cannot be regenerated from its inactive…
Pharmacologic Class:
Vitamin B12
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (2)
Effect of Methylcobalamin and Cyanocobalamin Consumption on Vitamin B12 Nutritional Status
Started Sep 2023
54 enrolled
Vitamin B12 Nutritional Deficiency
Characterization of Cyanocobalamin in Healthy Voluteers After Intranasal and Intramuscual Administration
Started Feb 2011
16 enrolled
Focus: Bioavailability
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.