NDAORALTABLET
Approved
Jun 1961
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
4/8 — Partial
NARDIL (phenelzine sulfate) by Pfizer is clinical pharmacology monoamine oxidase is a complex enzyme system, widely distributed throughout the body. First approved in 1961.
Drug data last refreshed 15h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
NARDIL (phenelzine sulfate) is a monoamine oxidase inhibitor (MAOI) oral tablet approved in 1961 for depression. It works by inhibiting monoamine oxidase, a complex enzyme system that regulates neurotransmitter levels including serotonin, norepinephrine, and dopamine. The drug is indicated for patients with major depressive disorder, particularly those who have not responded to other antidepressants.
$0.116MPart D
LOE ApproachingDeclining
Mature product with minimal Medicare claims and declining uptake; commercial team likely focused on retention and specialty care partnerships rather than growth expansion.
Mechanism of Action
CLINICAL PHARMACOLOGY Monoamine oxidase is a complex enzyme system, widely distributed throughout the body. Drugs that inhibit monoamine oxidase in the laboratory are associated with a number of clinical effects. Thus, it is unknown whether MAO inhibition per se, other pharmacologic actions, or an…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (1)
Phenelzine Sulfate and Docetaxel in Treating Patients With Prostate Cancer With Progressive Disease After First-Line Therapy With Docetaxel
Started Jul 2010
11 enrolled
Hormone-Resistant Prostate CancerMetastatic Prostatic AdenocarcinomaProstate Adenocarcinoma+1 more
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.