NDAORALTABLET
Approved
Mar 1960
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
1/8 — Limited
Drug data last refreshed 6h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
NAQUIVAL is a fixed-dose combination tablet containing reserpine (an antihypertensive alkaloid) and trichlormethiazide (a thiazide diuretic), approved in 1960 for oral treatment of hypertension. The combination works through dual mechanisms: reserpine depletes catecholamine stores in adrenergic neurons, while trichlormethiazide reduces sodium reabsorption in the distal convoluted tubule. This classic antihypertensive regimen targets patients requiring multi-drug blood pressure control.
LOE Approaching
Product is in late-stage lifecycle with minimal Part D exposure, indicating a small, stable team focused on legacy maintenance rather than expansion.
Mechanism of Action
Mechanism of action data is being enriched from DailyMed and FDA sources. Check back soon for updated drug intelligence.
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Career Relevance
NAQUIVAL offers minimal career growth opportunity; roles are primarily defensive, focused on maintaining compliance, managing regulatory obligations, and eventually executing product discontinuation. This is a legacy asset suitable for early-career professionals gaining foundational experience in mature product management or post-LOE portfolio stewardship.
Brand Manager (Legacy)
Worked on NAQUIVAL at Merck & Co.? Share your interview experience or compensation data (+7 days Pro)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.