NDAORALCAPSULE, EXTENDED RELEASE
Approved
Dec 2014
Lifecycle
Peak
Competitive Pressure
8/100
Data completeness
5/8 — Partial
NAMZARIC (memantine hydrochloride and donepezil hydrochloride) by AbbVie is medications: memantine hydrochloride and donepezil hydrochloride. Approved for moderate to severe dementia of the alzheimer's type in patients stabilized on 10 mg of donepezil hydrochloride once daily. First approved in 2014.
Drug data last refreshed 20h ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
NAMZARIC is a fixed-dose combination of memantine hydrochloride and donepezil hydrochloride approved for moderate to severe Alzheimer's disease dementia. It combines two complementary mechanisms: memantine acts as an NMDA receptor antagonist to modulate glutamate-mediated excitotoxicity, while donepezil enhances cholinergic function through acetylcholinesterase inhibition. The product is indicated for patients already stabilized on 10 mg donepezil daily, offering convenient once-daily extended-release dosing. Neither component halts neurodegeneration, but both address symptomatic cognitive decline.
$0.1BPart D
3.6 years to LOEMechanism of Action
medications: memantine hydrochloride and donepezil hydrochloride. Each of those medications is postulated to have a different mechanism in Alzheimer's disease. Memantine Persistent activation of central nervous system NMDA receptors by the excitatory amino acid glutamate has been hypothesized to…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.