NAMENDA
LOE ApproachingNDAORALSOLUTION
Approved
Apr 2005
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
4/8 — Partial
NAMENDA by AbbVie is n-methyl-d-aspartate (nmda) receptors by the excitatory amino acid glutamate has been hypothesized to contribute to the symptomatology of alzheimer's disease. Approved for moderate to severe dementia of the alzheimer's type, moderate to severe dementia of the alzheimer's type (). First approved in 2005.
Drug data last refreshed 8h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Namenda is an oral solution containing memantine, a small-molecule NMDA receptor antagonist approved for moderate to severe Alzheimer's dementia. It works by blocking glutamate excitotoxicity at NMDA receptors, though it does not prevent or slow neurodegeneration. The drug targets cognitive and functional decline in advanced Alzheimer's patients.
$0.063BPart D
LOE ApproachingProduct approaching loss of exclusivity with modest Part D utilization signals a contracting brand requiring defensive commercial strategies and potential cost management.
Mechanism of Action
N-methyl-D-aspartate (NMDA) receptors by the excitatory amino acid glutamate has been hypothesized to contribute to the symptomatology of Alzheimer's disease. Memantine is postulated to exert its therapeutic effect through its action as a low to moderate affinity uncompetitive (open-channel) NMDA…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.