NDATOPICALGEL
Approved
Jun 2013
Lifecycle
Peak
Competitive Pressure
0/100
Data completeness
4/8 — Partial
NAFTIN (naftifine hydrochloride) by Enterprise Therapeutics is 12. Approved for interdigital tinea pedis caused by the organisms trichophyton rubrum, trichophyton mentagrophytes, epidermophyton floccosum. First approved in 2013.
Drug data last refreshed 9m ago · AI intelligence enriched 4d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
NAFTIN (naftifine hydrochloride) is a topical allylamine antifungal gel approved in 2013 for treating interdigital tinea pedis caused by Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum. It works by inhibiting squalene 2,3-epoxidase, disrupting ergosterol biosynthesis in fungal cells. The drug demonstrates penetration into the stratum corneum with systemic accumulation reaching steady state after 11 days of daily application.
Peak6.4 years to LOE
NAFTIN is in its peak commercial phase with 6.4 years of patent protection remaining, suggesting stable but declining team investment through LOE.
Mechanism of Action
12.1 Mechanism of Action NAFTIN Gel is a topical antifungal drug [see ] . 12.2 Pharmacodynamics The pharmacodynamics of NAFTIN Gel have not been established . 12.3 Pharmacokinetics In vitro and in vivo bioavailability studies have demonstrated that naftifine penetrates the stratum corneum in…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.