NDATOPICALGEL
Approved
Jun 1990
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
4/8 — Partial
NAFTIN (naftifine hydrochloride) by Enterprise Therapeutics is 12. Approved for interdigital tinea pedis caused by the organisms trichophyton rubrum, trichophyton mentagrophytes, epidermophyton floccosum. First approved in 1990.
Drug data last refreshed 19h ago · AI intelligence enriched 6d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
NAFTIN (naftifine hydrochloride) is a topical antifungal gel belonging to the allylamine class, approved in 1990 for treating interdigital tinea pedis. It works by inhibiting squalene 2,3-epoxidase, disrupting fungal sterol biosynthesis and causing ergosterol depletion. The drug is active against Trichophyton rubrum, Trichophyton mentagrophytes, and Epidermophyton floccosum.
$2.0MPart D
LOE ApproachingAs an asset approaching loss of exclusivity with modest Medicare spending ($2M), NAFTIN brand teams face defensive positioning and will likely shift focus to retention strategies and generic transition planning.
Mechanism of Action
12.1 Mechanism of Action NAFTIN Gel is a topical antifungal drug [see ] . 12.2 Pharmacodynamics The pharmacodynamics of NAFTIN Gel have not been established . 12.3 Pharmacokinetics In vitro and in vivo bioavailability studies have demonstrated that naftifine penetrates the stratum corneum in…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.