MYDCOMBI
Peakphenylephrine hydrochloride; tropicamide
NDAOPHTHALMICSPRAY, METERED
Approved
May 2023
Lifecycle
Peak
Competitive Pressure
8/100
Data completeness
3/8 — Basic
MYDCOMBI (phenylephrine hydrochloride; tropicamide) is tropicamide, the anticholinergic component of mydcombi, blocks the responses of the sphincter muscle of the iris, dilating the pupil (mydriasis). First approved in 2023.
Drug data last refreshed 1h ago · AI intelligence enriched 1mo ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
MYDCOMBI is a fixed-dose combination ophthalmic spray containing phenylephrine hydrochloride (alpha-1 adrenergic agonist) and tropicamide (anticholinergic agent) approved in May 2023 for mydriasis in diagnostic and therapeutic ophthalmic procedures. The dual mechanism dilates the pupil through both iris sphincter muscle relaxation and iris dilator muscle contraction, providing rapid and sustained mydriasis without systemic absorption.
Peak4.7 years to LOE
Early-stage peak product with high competitive intensity (score 8/10) suggests active brand-building phase with potential for commercial team expansion in field sales and marketing roles.
Mechanism of Action
Tropicamide, the anticholinergic component of MYDCOMBI, blocks the responses of the sphincter muscle of the iris, dilating the pupil (mydriasis). Phenylephrine hydrochloride, the alpha-1 adrenergic agonist component of MYDCOMBI, acts as a mydriatic agent by contracting the dilator muscle of the…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Why This Matters for Your Career
LOE in ~5 years — strategic planning for patent cliff underway
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.