NDAORALCAPSULEPriority Review
Approved
Dec 1992
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
18
Mechanism of Action
Mechanism of Action Rifabutin inhibits DNA-dependent RNA polymerase in susceptible strains of Escherichia coli and Bacillus subtilis but not in mammalian cells. In resistant strains of E. coli , rifabutin, like rifampin, did not inhibit this enzyme. It is not known whether rifabutin inhibits…
Pharmacologic Class:
Rifamycin Antimycobacterial
Clinical Trials (5)
A Study of Rifabutin and MK-4646 in Healthy Participants (MK-4646-004)
Started Oct 2025
18 enrolled
Healthy
Study to Investigate the Penetration of Rifabutin Into the Lung After Multiple Intravenous Administrations of BV100
Started Sep 2023
35 enrolled
Bacterial Infections
Effect of Rifabutin on the Pharmacokinetics of Oral Cabotegravir in Healthy Subjects
Started Jun 2017
15 enrolled
Infection, Human Immunodeficiency VirusHIV Infections
Drug-drug Interaction (DDI) Rifabutin
Started May 2014
102 enrolled
Infection, Human Immunodeficiency Virus
Rifampin-Based Tuberculosis Treatment Versus Rifabutin-Based Tuberculosis Treatment in Persons With HIV
Started Jul 2013