MOVANTIK
Peaknaloxegol oxalate
NDAORALTABLET
Approved
Sep 2014
Lifecycle
Peak
Competitive Pressure
0/100
Clinical Trials
2
Data completeness
6/8 — Strong
MOVANTIK (naloxegol oxalate) is mu-opioid receptor. Approved for opioid-induced constipation (oic) in adult patients with chronic non-cancer pain, including patients with chronic pain related to prior cancer, its treatment. First approved in 2014.
Drug data last refreshed 3d ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
MOVANTIK (naloxegol oxalate) is an oral tablet approved in September 2014 for treating opioid-induced constipation (OIC) in adult patients with chronic non-cancer pain, including those with prior cancer-related pain. It is a PEGylated derivative of naloxone that functions as a peripherally-acting mu-opioid receptor antagonist, selectively blocking opioid effects in the gastrointestinal tract while minimizing CNS penetration through P-glycoprotein substrate properties. This mechanism allows it to relieve constipation without compromising central opioid analgesia. MOVANTIK occupies a distinct position in the OIC market as a peripheral antagonist alternative to laxatives and other GI motility agents.
$0.0BPart D
5.9 years to LOEMechanism of Action
mu-opioid receptor. When administered at the recommended dose levels, naloxegol functions as a peripherally-acting mu-opioid receptor antagonist in tissues, such as the gastrointestinal tract, thereby decreasing the constipating effects of opioids. Naloxegol is a PEGylated derivative of naloxone…
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.