NDAORALCONCENTRATE
Approved
Dec 1979
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
MOBAN (molindone hydrochloride) by Molecular Devices is clinical pharmacology molindone hydrochloride has a pharmacological profile in laboratory animals which predominantly resembles that of other antipsychotic agents causing reduction of spontaneous locomotion and aggressiveness, suppression of a conditioned response and antagonism of the bizarre stereotyped behavior and hyperactivity induced by amphetamines. Approved for schizophrenia. First approved in 1979.
Drug data last refreshed Yesterday · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
MOBAN (molindone hydrochloride) is a first-generation oral antipsychotic approved in 1979 for schizophrenia treatment. It reduces spontaneous locomotion and aggressiveness while suppressing bizarre behavior and hyperactivity, achieving antipsychotic effects without muscle relaxation. The drug works through antagonism at the ascending reticular activating system and is rapidly absorbed with a 24–36 hour duration of action per single dose.
LOE Approaching
As a legacy first-generation antipsychotic approaching loss of exclusivity, MOBAN brand roles are likely contracting with limited field and marketing headcount.
Mechanism of Action
CLINICAL PHARMACOLOGY Molindone Hydrochloride has a pharmacological profile in laboratory animals which predominantly resembles that of other antipsychotic agents causing reduction of spontaneous locomotion and aggressiveness, suppression of a conditioned response and antagonism of the bizarre…
Indications (1)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
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