NDAOPHTHALMICFOR SOLUTION
Approved
Sep 1993
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
MIOCHOL-E (acetylcholine chloride) by Bausch + Lomb is clinical pharmacology acetylcholine is a naturally occurring neurohormone which mediates nerve impulse transmission at all cholinergic sites involving somatic and autonomic nerves. First approved in 1993.
Drug data last refreshed 21h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Miochol-E (acetylcholine chloride) is an intraocular cholinergic agent administered topically during ophthalmic surgery to produce rapid miosis (pupil constriction). It works by directly stimulating muscarinic receptors on the iris sphincter muscle, mimicking acetylcholine's natural neurotransmitter action. The drug is used to facilitate anterior chamber surgery by maintaining a constricted pupil throughout the procedure.
LOE Approaching
Approaching loss of exclusivity with moderate competitive pressure (30%), suggesting a defensive rather than growth-focused commercial team.
Mechanism of Action
CLINICAL PHARMACOLOGY Acetylcholine is a naturally occurring neurohormone which mediates nerve impulse transmission at all cholinergic sites involving somatic and autonomic nerves. After release from the nerve ending, acetylcholine is rapidly inactivated by the enzyme acetylcholinesterase by…
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Career Relevance
Working on Miochol-E offers stability in a niche ophthalmic surgical space but limited career growth opportunities due to mature lifecycle and zero linked job openings. This is a maintenance-mode product requiring strong relationship management with ophthalmologists and surgical centers rather than market expansion.
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.