MINOCIN
LOE ApproachingNDAORALSUSPENSION
Approved
Oct 1972
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
MINOCIN by Bausch + Lomb is clinical pharmacology following a single dose of minocin 200 mg administered intravenously to 10 healthy male subjects, serum concentrations of minocycline ranged from 2. Approved for infections caused by the following gram-negative bacteria, infections caused by the following gram-positive bacteria, the treatment of the following infections due to susceptible isolates of the designated bacteria: rocky mountain spotted fever and 5 more indications. First approved in 1972.
Drug data last refreshed 18h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
MINOCIN (minocycline) is an oral tetracycline antibiotic suspension approved in 1972 that inhibits bacterial protein synthesis to treat a broad spectrum of Gram-positive and Gram-negative bacterial infections, including rickettsial diseases such as Rocky Mountain spotted fever and typhus. The drug demonstrates bacteriostatic activity with a serum half-life of 15-23 hours in healthy subjects, allowing flexible dosing regimens of 100 mg every 12 hours or 200 mg once daily.
LOE Approaching
Product is approaching loss of exclusivity with moderate competitive pressure (30%), signaling a contracting team focused on maximizing remaining brand value and potential portfolio optimization.
Mechanism of Action
CLINICAL PHARMACOLOGY Following a single dose of Minocin 200 mg administered intravenously to 10 healthy male subjects, serum concentrations of minocycline ranged from 2.52 to 6.63 mcg/mL (average 4.18 mcg/mL) at the end of infusion and 0.82 to 2.64 mcg/mL (average 1.38 mcg/mL) after 12 hours. In a…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.