NDAORALTABLET, EXTENDED RELEASE
Approved
Jan 1992
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
3/8 — Basic
MINIPRESS XL (prazosin hydrochloride) by Pfizer is clinical pharmacology the exact mechanism of the hypotensive action of prazosin is unknown. First approved in 1992.
Drug data last refreshed 18h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
MINIPRESS XL is an extended-release oral tablet formulation of prazosin hydrochloride, an alpha-adrenergic receptor antagonist used to treat hypertension. It works by blocking postsynaptic alpha-adrenoceptors to reduce peripheral vascular resistance, lowering blood pressure without causing reflex tachycardia. The drug has demonstrated stable hemodynamics with minimal impact on heart rate, renal function, or lipid profiles.
LOE Approaching
Product is approaching loss of exclusivity with moderate competitive pressure (30), signaling potential downsizing of brand team or transition to generic defense strategies.
Mechanism of Action
CLINICAL PHARMACOLOGY The exact mechanism of the hypotensive action of prazosin is unknown. Prazosin causes a decrease in total peripheral resistance and was originally thought to have a direct relaxant action on vascular smooth muscle. Recent animal studies, however, have suggested that the…
Indications
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.