NDAORALCAPSULE
Approved
Dec 1996
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
3/8 — Basic
MICROZIDE (hydrochlorothiazide) by Teva is clinical pharmacology hydrochlorothiazide blocks the reabsorption of sodium and chloride ions, and it thereby increases the quantity of sodium traversing the distal tubule and the volume of water excreted. First approved in 1996.
Drug data last refreshed 13h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
MICROZIDE (hydrochlorothiazide) is a thiazide diuretic oral capsule that reduces blood pressure by blocking sodium and chloride reabsorption in the distal tubule, thereby increasing sodium and water excretion. It is indicated for hypertension management and functions as an antihypertensive agent with onset within 2 hours and peak effect at 4 hours. The drug works through both acute reductions in blood volume and chronic decreases in peripheral vascular resistance.
LOE Approaching
As LOE approaches, commercial teams face margin compression and shifting focus toward generic co-promotion or bundled offerings; brand team sizing likely to contract.
Mechanism of Action
CLINICAL PHARMACOLOGY Hydrochlorothiazide blocks the reabsorption of sodium and chloride ions, and it thereby increases the quantity of sodium traversing the distal tubule and the volume of water excreted. A portion of the additional sodium presented to the distal tubule is exchanged there for…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.