METRONIDAZOLE
LOE ApproachingNDAINJECTIONINJECTABLE
Approved
Nov 1983
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
4/8 — Partial
METRONIDAZOLE by Abbott is clinical pharmacology absorption disposition of metronidazole in the body is similar for both oral and intravenous dosage forms. Approved for the treatment of asymptomatic t, the treatment of acute intestinal amebiasis (amebic dysentery), amebic liver abscess and 1 more indications. First approved in 1983.
Drug data last refreshed 7h ago · AI intelligence enriched 2d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Metronidazole is a small-molecule nitroimidazole antibiotic with bactericidal activity against anaerobic bacteria and protozoa. It is indicated for treatment of asymptomatic trichomoniasis, acute intestinal amebiasis, amebic liver abscess, and serious infections caused by susceptible anaerobic bacteria. The drug works by disrupting microbial DNA through intracellular reduction of its nitro group.
LOE Approaching
Product is nearing loss of exclusivity with significant generic competition; team focus shifts from growth to market defense and cost management.
Mechanism of Action
CLINICAL PHARMACOLOGY Absorption Disposition of metronidazole in the body is similar for both oral and intravenous dosage forms. Following oral administration, metronidazole is well absorbed, with peak plasma concentrations occurring between one and two hours after administration. Plasma…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.