NDAINJECTIONINJECTABLE
Approved
Nov 1946
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
2/8 — Basic
METHERGINE (methylergonovine maleate) by Teva is clinical pharmacology methergine (methylergonovine maleate) acts directly on the smooth muscle of the uterus and increases the tone, rate, and amplitude of rhythmic contractions. First approved in 1946.
Drug data last refreshed 4h ago · AI intelligence enriched 4d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
Methergine (methylergonovine maleate) is a potent uterotonic ergot alkaloid approved in 1946 for prevention and treatment of postpartum hemorrhage. It acts directly on uterine smooth muscle to induce rapid, sustained tetanic contractions that shorten the third stage of labor and reduce blood loss. The drug is administered via intramuscular, intravenous, or oral routes with onset of action ranging from immediate (IV) to 5-10 minutes (oral).
LOE Approaching
As a legacy product approaching loss of exclusivity with moderate competitive pressure (30), team size is likely stable to contracting; careers here focus on defending existing market share and optimizing manufacturing efficiency rather than expansion.
Mechanism of Action
CLINICAL PHARMACOLOGY Methergine (methylergonovine maleate) acts directly on the smooth muscle of the uterus and increases the tone, rate, and amplitude of rhythmic contractions. Thus, it induces a rapid and sustained tetanic uterotonic effect which shortens the third stage of labor and reduces…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.