METFORMIN HYDROCHLORIDE

Post-LOE

metformin hydrochloride

ANDAORALSOLUTION
Approved
Aug 2022
Lifecycle
Post-LOE
Competitive Pressure
30/100
Clinical Trials
18

Mechanism of Action

2 diabetes mellitus, lowering both basal and postprandial plasma glucose. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. With metformin therapy, insulin secretion…

Clinical Trials (5)

NCT06823856Phase 1Completed

Pharmacokinetics and Bioequivalence Study of Empagliflozin+Metformin Hydrochloride 12.5 mg/1000 mg Film-coated Tablets (Gedeon Richter Plc., Hungary) Versus Synjardy 12.5 mg/1000 mg Film-coated Tablets (Boehringer Ingelheim International GmbH, Germany)

Started May 2025
64 enrolled
Diabetes Mellitus Type 2
NCT06792968Phase 1Completed

Pharmacokinetics and Bioequivalence Study of Empagliflozin+Metformin Hydrochloride 5 mg/1000 mg Film-coated Tablets (Gedeon Richter Plc., Hungary) Versus Synjardy 5 mg/1000 mg Film-coated Tablets (Boehringer Ingelheim International GmbH, Germany)

Started Mar 2025
64 enrolled
Diabetes Mellitus Type 2
NCT06766500Phase 1Completed

Pharmacokinetics and Bioequivalence Study of Empagliflozin+Metformin Hydrochloride 5 mg/850 mg Film-coated Tablets (Gedeon Richter Plc., Hungary) Versus Synjardy® 5 mg/850 mg Film-coated Tablets (Boehringer Ingelheim International GmbH, Germany)

Started Jan 2025
64 enrolled
Diabetes Mellitus Type 2
NCT04288778Phase 4Completed

A Study to Assess Safety of Canagliflozin and Metformin Hydrochloride Combination Given as a Supplement to Diet and Exercise to Improve Blood Sugar Level in Indian Adult Participants With Diabetes

Started Nov 2020
276 enrolled
Diabetes Mellitus
NCT03048500Phase 2Unknown

Nivolumab and Metformin Hydrochloride in Treating Patients With Stage III-IV Non-small Cell Lung Cancer That Cannot Be Removed by Surgery

Started Jul 2017
17 enrolled
Recurrent Non-Small Cell Lung CarcinomaStage III Non-Small Cell Lung CancerStage IIIA Non-Small Cell Lung Cancer+2 more