NDAORALSOLUTIONPriority Review
Approved
Mar 2023
Lifecycle
Peak
Competitive Pressure
8/100
Clinical Trials
30
Data completeness
4/8 — Partial
Priority Review
Drug data last refreshed 8h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
MEKINIST (trametinib) is an oral small-molecule MEK inhibitor approved in March 2023 for oncology indications. It is administered as a solution formulation and works by inhibiting mitogen-activated protein kinase (MEK) signaling in cancer cells. The drug targets patients with specific mutations in the MAPK pathway.
$173MPart D
Peak4.6 years to LOEAt peak lifecycle with $173M in Part D spending and 12,301 claims in 2023, indicating robust commercial performance and likely larger brand and field teams focused on market penetration and indication expansion.
Mechanism of Action
Mechanism of action data is being enriched from DailyMed and FDA sources. Check back soon for updated drug intelligence.
Indications
Indication data is being enriched from DailyMed and FDA labeling. Check back soon for approved therapeutic uses.
Clinical Trials (30)
DETERMINE Trial Treatment Arm 07: Dabrafenib in Combination With Trametinib in Adult, Paediatric and Teenage/Young Adult Patients With BRAF V600 Mutation-Positive Cancers.
Started Apr 2026
30 enrolled
Haematological MalignancyMalignant NeoplasmLymphoproliferative Disorders+17 more
XP-102 and XP-102 in Combination With Trametinib in Advanced Solid Tumor Patients With a BRAF V600 Mutation
Started Dec 2025
221 enrolled
CancerBRAF V600 MutationMelanoma+3 more
24VA021; VATCH Trametinib for Ras/MAPK Pathway VAs
Started Aug 2025
45 enrolled
Ras/MAPK Pathway Vascular AnomaliesVascular AnomaliesVascular Anomaly
Trametinib Plus Anlotinib Combined With Tislelizumab in KRAS-mutant NSCLC
Started Jul 2024
60 enrolled
KRAS Mutation-Related TumorsAdvanced Lung CancerRefractory Tumor
A Study to Assess Naporafenib (ERAS-254) Administered With Trametinib in Patients With NRAS-mutant Melanoma (SEACRAFT-2)
Started Apr 2024
78 enrolled
Advanced or Metastatic NRAS-mutant Melanoma
Worked on MEKINIST at Novartis? Share your interview experience or compensation data (+7 days Pro)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.