MAGNESIUM SULFATE

LOE Approaching

magnesium sulfate heptahydrate

NDAINTRAMUSCULAR, INTRAVENOUSSOLUTION
Approved
Sep 1986
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
3

Mechanism of Action

CLINICAL PHARMACOLOGY: Magnesium is an important cofactor for enzymatic reactions and plays an important role in neurochemical transmission and muscular excitability. As a nutritional adjunct in hyperalimentation, the precise mechanism of action for magnesium is uncertain. Early symptoms of…

Clinical Trials (3)

NCT01333488Phase 2Terminated

Mild Hypothermia and Supplemental Magnesium Sulfate Infusion in Severe Traumatic Brain Injury (TBI) Subjects

Started Dec 2011
6 enrolled
Traumatic Brain Injury
NCT01099449Phase 3Completed

Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy

Started Jun 2010
362 enrolled
Chemotherapeutic Agent ToxicityColorectal CancerNeuropathy+1 more
NCT00316914Phase 3Completed

Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity Caused By Oxaliplatin in Patients Receiving Combination Chemotherapy for Stage II, Stage III, or Stage IV Colorectal Cancer That Has Been Completely Removed By Surgery

Started Jan 2006
104 enrolled
Colorectal CancerNeurotoxicity