MAGNESIUM HYDROXIDE AND OMEPRAZOLE AND SODIUM BICARBONATE
LOE Approachingmagnesium hydroxide; omeprazole; sodium bicarbonate
NDAORALTABLET
Approved
Dec 2009
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
MAGNESIUM HYDROXIDE AND OMEPRAZOLE AND SODIUM BICARBONATE (magnesium hydroxide; omeprazole; sodium bicarbonate) is clinical pharmacology omeprazole is acid labile and thus rapidly degraded by gastric acid. Approved for heartburn, other symptoms associated with gerd. First approved in 2009.
Drug data last refreshed 16h ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
ZEGERID (omeprazole with magnesium hydroxide and sodium bicarbonate) is a buffered, immediate-release proton pump inhibitor formulation designed to protect acid-labile omeprazole from gastric degradation. It treats heartburn and other symptoms associated with gastroesophageal reflux disease (GERD) by raising gastric pH and rapidly suppressing acid secretion. The combination antacid-PPI formulation enables faster omeprazole absorption and earlier symptom relief compared to standard omeprazole tablets.
LOE Approaching
Product approaching loss of exclusivity with moderate competitive pressure (30/100), signaling transition from growth-stage to defense and managed decline phase requiring cost-control and volume-protection strategies.
Mechanism of Action
CLINICAL PHARMACOLOGY Omeprazole is acid labile and thus rapidly degraded by gastric acid. ZEGERID with Magnesium Hydroxide is an immediate-release chewable tablet formulation that contains an antacid component (sodium bicarbonate plus magnesium hydroxide) which raises the gastric pH and thus…
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.