NDAORALCAPSULE
Approved
Jun 2005
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
3/8 — Basic
LYRICA (pregabalin) by Teva is 2 -delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. First approved in 2005.
Drug data last refreshed 3d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
LYRICA (pregabalin) is an oral small-molecule anticonvulsant and neuropathic pain medication that binds to the alpha-2-delta subunit of voltage-gated calcium channels in the central nervous system. It is approved for six indications including fibromyalgia, epilepsy, diabetic peripheral neuropathy, postherpetic neuralgia, generalized anxiety disorder, and restless legs syndrome. The drug works by reducing calcium-dependent neurotransmitter release in the spinal cord and modulating descending pain pathways, without directly affecting GABA or opioid receptors.
LOE Approaching
As LYRICA approaches loss of exclusivity, brand teams face resource contraction with growing emphasis on lifecycle extension strategies and transition planning to support generic erosion management.
Mechanism of Action
2 -delta site (an auxiliary subunit of voltage-gated calcium channels) in central nervous system tissues. Although the mechanism of action of pregabalin has not been fully elucidated, results with genetically modified mice and with compounds structurally related to pregabalin (such as gabapentin)…
Indications
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.