NDAINJECTIONINJECTABLE
Approved
Dec 1995
Lifecycle
Peak
Competitive Pressure
8/100
Clinical Trials
12
Data completeness
6/8 — Strong
LUPRON DEPOT (leuprolide acetate) by AbbVie is acetate, a gnrh agonist, acts as an inhibitor of gonadotropin secretion. Approved for prostate cancer, central precocious puberty, endometriosis and 1 more indications. First approved in 1995.
Drug data last refreshed 23h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
LUPRON DEPOT (leuprolide acetate) is a GnRH agonist injectable approved in 1995 that suppresses gonadotropin secretion and inhibits ovarian and testicular steroidogenesis. It is indicated for prostate cancer, metastatic prostate cancer, endometriosis, and central precocious puberty. The drug works by initial stimulation followed by continuous suppression of sex hormone production, resulting in tumor growth inhibition in hormone-dependent cancers.
Peak4.8 years to LOE
Annual spending of $129M indicates a mature, stable revenue base with established field teams, but competitive pressure (8/10) and approaching LOE suggest defensive positioning.
Mechanism of Action
acetate, a GnRH agonist, acts as an inhibitor of gonadotropin secretion. Animal studies indicate that following an initial stimulation, continuous administration of leuprolide acetate results in suppression of ovarian and testicular steroidogenesis. This effect was reversible upon discontinuation…
Indications (4)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.