NDAORALTABLET
Approved
Feb 1975
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
LOXITANE (loxapine succinate) by Teva is clinical pharmacology pharmacodynamics pharmacologically, loxapine is an antipsychotic for which the exact mode of action has not been established. Approved for schizophrenia, comatose, severe drug-induced depressed states (alcohol and 3 more indications. First approved in 1975.
Drug data last refreshed 11h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
LOXITANE (loxapine succinate) is a first-generation antipsychotic oral tablet approved in 1975 for schizophrenia and severe drug-induced depressed states. The drug works by modulating subcortical inhibitory areas, producing sedation within 20-30 minutes and suppressing aggressive behavior, though its exact mechanism remains incompletely understood. Loxapine is rapidly absorbed, extensively metabolized, and excreted primarily within 24 hours.
LOE Approaching
As a legacy antipsychotic approaching loss of exclusivity, LOXITANE faces declining commercial opportunity with minimal team expansion and focus on cost management rather than growth initiatives.
Mechanism of Action
CLINICAL PHARMACOLOGY Pharmacodynamics Pharmacologically, loxapine is an antipsychotic for which the exact mode of action has not been established. However, changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with such…
Indications (6)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.