NDAORALTABLET
Approved
Feb 1975
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
1
Data completeness
4/8 — Partial
LOXITANE (loxapine succinate) by Teva is clinical pharmacology pharmacodynamics pharmacologically, loxapine is an antipsychotic for which the exact mode of action has not been established. Approved for schizophrenia, comatose, severe drug-induced depressed states (alcohol and 3 more indications. First approved in 1975.
Drug data last refreshed 6h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
LOXITANE (loxapine succinate) is a first-generation antipsychotic tablet approved in 1975 for treating schizophrenia and severe drug-induced depressed states. The exact mechanism remains unclear, but it reduces excitability in subcortical inhibitory areas, producing sedation and behavioral calming within 20–30 minutes. The drug is rapidly absorbed, extensively metabolized, and excreted primarily within 24 hours.
LOE Approaching
As loss of exclusivity approaches, the brand team will likely shrink; career opportunities may shift toward generic optimization or transition to higher-growth products.
Mechanism of Action
CLINICAL PHARMACOLOGY Pharmacodynamics Pharmacologically, loxapine is an antipsychotic for which the exact mode of action has not been established. However, changes in the level of excitability of subcortical inhibitory areas have been observed in several animal species in association with such…
Indications (6)
Worked on LOXITANE at Teva? Share your interview experience or compensation data (+7 days Pro)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.