NDATOPICALSOLUTIONPriority Review
Approved
Feb 1975
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
8
Data completeness
3/8 — Basic
Priority Review
LOTRIMIN (clotrimazole) by Merck & Co. is clinical pharmacology clotrimazole is a broad-spectrum antifungal agent that is used for the treatment of dermal infections caused by various species of pathogenic dermatophytes, yeasts, and malassezia furfur . First approved in 1975.
Drug data last refreshed 3d ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
LOTRIMIN (clotrimazole) is a broad-spectrum topical antifungal agent approved in 1975 for treating dermal infections caused by dermatophytes, yeasts, and Malassezia furfur. It works by disrupting fungal cell membranes through inhibition of ergosterol synthesis, causing leakage of intracellular contents and cell death. The drug is indicated for vulvovaginal candidiasis, oral candidiasis, and various mycoses including otomycosis.
LOE Approaching
Product approaching loss of exclusivity with minimal current promotional investment; commercial team likely transitioning to defensive positioning or product line consolidation.
Mechanism of Action
CLINICAL PHARMACOLOGY Clotrimazole is a broad-spectrum antifungal agent that is used for the treatment of dermal infections caused by various species of pathogenic dermatophytes, yeasts, and Malassezia furfur . The primary action of clotrimzole is against dividing and growing organisms. In vitro ,…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.