NDAORALTABLET
Approved
May 1992
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
5/8 — Partial
LOTENSIN HCT (benazepril hydrochloride and hydrochlorothiazide) by Bausch Health is clinical pharmacology mechanism of action benazepril and benazeprilat inhibit angiotensin converting enzyme (ace) in human subjects and in animals. Approved for hypertension. First approved in 1992.
Drug data last refreshed 20h ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
LOTENSIN HCT is a fixed-dose combination of benazepril (ACE inhibitor) and hydrochlorothiazide (thiazide diuretic) for oral treatment of hypertension. It works by inhibiting angiotensin-converting enzyme to reduce angiotensin II-mediated vasoconstriction while simultaneously promoting sodium and water excretion via diuresis. The combination approach counters the potassium-wasting effect of the diuretic with the potassium-sparing tendency of the ACE inhibitor.
$0.010BPart D
LOE ApproachingDeclining
Product is in late-stage lifecycle with minimal Medicare spending ($10K in 2023), indicating a shrinking brand footprint and reduced commercial investment.
Mechanism of Action
CLINICAL PHARMACOLOGY Mechanism of Action Benazepril and benazeprilat inhibit angiotensin converting enzyme (ACE) in human subjects and in animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.