NDAORALTABLET
Approved
May 1992
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
2
Data completeness
6/8 — Strong
LOTENSIN HCT (benazepril hydrochloride and hydrochlorothiazide) by Bausch Health is clinical pharmacology mechanism of action benazepril and benazeprilat inhibit angiotensin converting enzyme (ace) in human subjects and in animals. Approved for hypertension. First approved in 1992.
Drug data last refreshed 5h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
LOTENSIN HCT is a fixed-dose combination oral tablet containing benazepril hydrochloride (an ACE inhibitor) and hydrochlorothiazide (a thiazide diuretic) for the treatment of hypertension. It works by inhibiting angiotensin-converting enzyme to reduce angiotensin II-mediated vasoconstriction and by promoting sodium and chloride excretion to reduce plasma volume. The combination approach balances the potassium-elevating effect of ACE inhibition with the potassium-lowering effect of diuresis.
$0.01BPart D
LOE ApproachingDeclining
Product is approaching loss of exclusivity with minimal recent spending and low claims volume, indicating reduced commercial investment and team contraction likelihood.
Mechanism of Action
CLINICAL PHARMACOLOGY Mechanism of Action Benazepril and benazeprilat inhibit angiotensin converting enzyme (ACE) in human subjects and in animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.