NDAORALTABLET
Approved
May 1992
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
5/8 — Partial
LOTENSIN HCT (benazepril hydrochloride and hydrochlorothiazide) by Bausch Health is clinical pharmacology mechanism of action benazepril and benazeprilat inhibit angiotensin converting enzyme (ace) in human subjects and in animals. Approved for hypertension. First approved in 1992.
Drug data last refreshed 4h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
LOTENSIN HCT is a fixed-dose combination of benazepril hydrochloride (ACE inhibitor) and hydrochlorothiazide (thiazide diuretic) approved for hypertension management. It works by inhibiting angiotensin-converting enzyme to reduce vasopressor activity and aldosterone secretion, while the diuretic component reduces plasma volume through increased sodium and chloride excretion. The combination allows synergistic blood pressure reduction with potassium-sparing effects due to ACE inhibitor offsetting diuretic-induced potassium loss.
$0.01BPart D
LOE ApproachingDeclining
As LOE approaches, commercial teams are consolidating; expect smaller field footprint and shift toward managed care and generic transition planning.
Mechanism of Action
CLINICAL PHARMACOLOGY Mechanism of Action Benazepril and benazeprilat inhibit angiotensin converting enzyme (ACE) in human subjects and in animals. ACE is a peptidyl dipeptidase that catalyzes the conversion of angiotensin I to the vasoconstrictor substance, angiotensin II. Angiotensin II also…
Worked on LOTENSIN HCT at Bausch Health? Share your interview experience or compensation data (+7 days Pro)
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.