LORAZEPAM

Post-LOE

lorazepam

ANDAORALTABLET
Approved
Jul 2007
Lifecycle
Post-LOE
Competitive Pressure
30/100
Clinical Trials
5

Mechanism of Action

CLINICAL PHARMACOLOGY Studies in healthy volunteers show that in single high doses lorazepam has a tranquilizing action on the central nervous system with no appreciable effect on the respiratory or cardiovascular systems. Lorazepam is readily absorbed with an absolute bioavailability of 90%. Peak…

Pharmacologic Class:

Benzodiazepine

Clinical Trials (5)

NCT01994668Phase 1Completed

Phase 1 Study to Characterize the Safety and Pharmacokinetics of Single Intravenous Dose of Lorazepam in Healthy Japanese Adult Subjects

Started Jan 2014
8 enrolled
Healthy
NCT01275144Phase 1Completed

A Study of the Effect of LY2216684 on Lorazepam

Started Dec 2010
28 enrolled
Major Depressive Disorder
NCT00465244Phase 2/3Withdrawn

Seizure Therapy With Intravenous Levetiracetam and Lorazepam

Started Jan 2008
0
Seizures
NCT00546624Phase 2Completed

GEM 1.5 mg b.i.d. to 4.5 mg b.i.d. Versus Lorazepam in GAD (0777-026)

Started Nov 2002
38 enrolled
Anxiety Disorder
NCT00249171Phase 4Completed

A Study of Risperidone in Combination With Lorazepam Compared With Standard Therapy for Emergency Treatment of Schizophrenic Patients

Started Jun 2001
226 enrolled
SchizophreniaPsychotic DisordersEmergency Treatment