LOPRESSOR
LOE ApproachingNDAINJECTIONINJECTABLEPriority Review
Approved
Mar 1984
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
4
Data completeness
4/8 — Partial
Priority Review
LOPRESSOR by Novartis is 12. Approved for the treatment of hemodynamically stable adult patients with myocardial infarction, to reduce the risk of cardiovascular mortality, the treatment of hemodynamically stable adult patients with myocardial infarction (mi) to reduce cardiovascular mortality. First approved in 1984.
Drug data last refreshed 12h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
LOPRESSOR (metoprolol) is a beta-1 selective adrenergic receptor antagonist administered intravenously for the treatment of hemodynamically stable acute myocardial infarction. It reduces cardiovascular mortality by slowing heart rate, decreasing cardiac output, and reducing blood pressure, thereby limiting myocardial oxygen demand during acute cardiac events.
LOE Approaching
As an injectable post-MI therapeutic approaching loss of exclusivity, LOPRESSOR brand team faces competitive pressure (score: 30) and likely operates as a lean, specialized commercial unit focused on hospital and emergency care channels.
Mechanism of Action
12.1 Mechanism of Action Metoprolol is a beta 1 -selective (cardioselective) adrenergic receptor blocking agent. This preferential effect is not absolute, however, and at higher plasma concentrations, metoprolol also inhibits beta 2 -adrenoreceptors, chiefly located in the bronchial and vascular…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.