LOPRESSOR
LOE ApproachingNDAORALTABLET, EXTENDED RELEASE
Approved
Dec 1989
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
4
Data completeness
4/8 — Partial
LOPRESSOR by Novartis is 12. Approved for the treatment of hemodynamically stable adult patients with myocardial infarction, to reduce the risk of cardiovascular mortality, the treatment of hemodynamically stable adult patients with myocardial infarction (mi) to reduce cardiovascular mortality. First approved in 1989.
Drug data last refreshed 11h ago · AI intelligence enriched 1w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
LOPRESSOR (metoprolol) is a beta-1 selective adrenergic receptor blocking agent indicated for treatment of hemodynamically stable acute myocardial infarction to reduce cardiovascular mortality. It works by selectively blocking beta-1 adrenergic receptors, thereby reducing heart rate, cardiac output, and blood pressure, with preserved vasodilatory effects at therapeutic doses due to beta-1 selectivity.
LOE Approaching
Product approaching loss of exclusivity with moderate competitive pressure (score: 30), signaling potential team restructuring and transition focus toward generic optimization.
Mechanism of Action
12.1 Mechanism of Action Metoprolol is a beta 1 -selective (cardioselective) adrenergic receptor blocking agent. This preferential effect is not absolute, however, and at higher plasma concentrations, metoprolol also inhibits beta 2 -adrenoreceptors, chiefly located in the bronchial and vascular…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.