LOPRESSOR
LOE ApproachingNDAORALTABLET, EXTENDED RELEASE
Approved
Dec 1989
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
LOPRESSOR by Novartis is 12. Approved for the treatment of hemodynamically stable adult patients with myocardial infarction, to reduce the risk of cardiovascular mortality, the treatment of hemodynamically stable adult patients with myocardial infarction (mi) to reduce cardiovascular mortality. First approved in 1989.
Drug data last refreshed 4d ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
LOPRESSOR (metoprolol) is a beta-1-selective adrenergic receptor blocking agent indicated for acute myocardial infarction. It reduces heart rate, cardiac output, and systolic blood pressure by selectively blocking beta-1 receptors in the heart while preserving some beta-2 activity in airways, making it safer for asthmatic patients than nonselective beta-blockers.
LOE Approaching
Product nearing loss of exclusivity with moderate competitive pressure (30%), indicating potential for small team focused on generic transition strategy and lifecycle management.
Mechanism of Action
12.1 Mechanism of Action Metoprolol is a beta 1 -selective (cardioselective) adrenergic receptor blocking agent. This preferential effect is not absolute, however, and at higher plasma concentrations, metoprolol also inhibits beta 2 -adrenoreceptors, chiefly located in the bronchial and vascular…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.