LIVMARLI

Launch

maralixibat chloride

NDAORALTABLET
Approved
Apr 2025
Lifecycle
Launch
Competitive Pressure
0/100
Clinical Trials
2

Mechanism of Action

(IBAT). It decreases the reabsorption of bile acids (primarily the salt forms) from the terminal ileum . Pruritus is a common symptom in patients with ALGS or PFIC and the pathophysiology of pruritus in patients with ALGS or PFIC is not completely understood. Although the complete mechanism by…

Clinical Trials (2)

NCT07290257Phase 4Recruiting

Long-Term Low-Intervention SafEty and Clinical Outcomes Clinical Study of LivmArli® in Patients With Alagille Syndrome in the European Union (LEAP-EU)

Started Sep 2025
100 enrolled
Alagille Syndrome
NCT06193928N/ARecruiting

Long-Term SafEty and Clinical Outcomes of LivmArli in Patients in the United States (LEAP-US)

Started Sep 2023
70 enrolled
Alagille SyndromeProgressive Familial Intrahepatic Cholestasis

Loss of Exclusivity

LOE Date
Oct 5, 2043
214 months away
Patent Expiry
Oct 5, 2043
Exclusivity Expiry
Mar 13, 2027

Patent Records (5)

Patent #ExpiryTypeUse Code
11260053
May 26, 2031
U-4187
11229661
Oct 26, 2032
U-4186
12350267
Oct 26, 2032
U-3973
11376251
Oct 26, 2032
U-4187
10512657
Oct 26, 2032
U-4186