NDAORALTABLET
Approved
May 2013
Lifecycle
Peak
Competitive Pressure
30/100
Data completeness
3/8 — Basic
LIPTRUZET (atorvastatin calcium; ezetimibe) by Merck & Co. is selective, competitive inhibitor of hmg-coa reductase, the rate-limiting enzyme that converts 3-hydroxy-3-‑methylglutaryl-coenzyme a to mevalonate, a precursor of sterols, including cholesterol. Approved for elevated total cholesterol (total-c), low-density lipoprotein cholesterol (ldl-c), apolipoprotein b (apo b) and 8 more indications. First approved in 2013.
Drug data last refreshed 47m ago · AI intelligence enriched 2w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
LIPTRUZET is a fixed-dose combination tablet containing atorvastatin calcium and ezetimibe, approved by FDA in 2013 for treatment of elevated cholesterol and triglycerides. It works by dual mechanism: atorvastatin inhibits HMG-CoA reductase to reduce hepatic cholesterol synthesis and increase LDL receptor uptake, while ezetimibe selectively blocks intestinal cholesterol absorption. The combination is indicated for primary and homozygous familial hyperlipidemia, mixed hyperlipidemia, and as adjunct to other lipid-lowering therapies.
Peak
Product is at peak commercial maturity with moderate competitive intensity (30/100), suggesting stable team size and sustained commercial investment from Merck.
Mechanism of Action
selective, competitive inhibitor of HMG-CoA reductase, the rate-limiting enzyme that converts 3-hydroxy-3-‑methylglutaryl-coenzyme A to mevalonate, a precursor of sterols, including cholesterol. In animal models, atorvastatin calcium lowers plasma cholesterol and lipoprotein levels by inhibiting…
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.