NDAIONTOPHORESIS, TOPICALPATCH
Approved
May 2004
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Data completeness
3/8 — Basic
LIDOSITE TOPICAL SYSTEM KIT (epinephrine; lidocaine hydrochloride) by AstraZeneca is impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. Approved for regional anesthesia, analgesia for surgery, dental and 4 more indications. First approved in 2004.
Drug data last refreshed 18h ago · AI intelligence enriched 21h ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
LIDOSITE is a topical iontophoretic patch combining lidocaine hydrochloride and epinephrine for rapid local anesthesia. It blocks nerve impulses by increasing electrical excitation threshold and slowing impulse propagation, with epinephrine acting as a vasoconstrictor to prolong anesthetic effect. The patch is indicated for regional anesthesia, surgical analgesia, and dental/oral procedures.
LOE Approaching
Product approaching loss of exclusivity with moderate competitive pressure (30%), indicating team focus shifting toward cost management and transition planning rather than growth initiatives.
Mechanism of Action
impulses, presumably by increasing the threshold for electrical excitation in the nerve, by slowing the propagation of the nerve impulse, and by reducing the rate of rise of the action potential. In general, the progression of anesthesia is related to the diameter, myelination, and conduction…
Indications (7)
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Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.