LEUKINE
LOE Approachingsargramostim
BLAINTRAVENOUSVIALPriority Review
Approved
Mar 1991
Lifecycle
LOE Approaching
Competitive Pressure
30/100
Clinical Trials
20
Data completeness
5/8 — Partial
Priority Review
LEUKINE (sargramostim) is (gm-csf) belongs to a group of growth factors termed colony-stimulating factors which support survival, clonal expansion, and differentiation of hematopoietic progenitor cells. First approved in 1991.
Drug data last refreshed 22h ago · AI intelligence enriched 3w ago
AI summarySynthesized from FDA + DailyMed + ClinicalTrials.gov data
LEUKINE (sargramostim) is a recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) approved in 1991 for mobilizing hematopoietic progenitor cells. It works by binding to specific cell surface receptors to promote division, differentiation, and activation of granulocytes, macrophages, and dendritic cells across the myeloid lineage. The drug supports bone marrow recovery and immune cell proliferation in patients undergoing chemotherapy or stem cell transplantation.
$0.003BPart D
LOE ApproachingDeclining
Nearing end-of-life with minimal Part D utilization (446 claims in 2023); brand team focus shifting toward managed decline and transition planning.
Mechanism of Action
(GM-CSF) belongs to a group of growth factors termed colony-stimulating factors which support survival, clonal expansion, and differentiation of hematopoietic progenitor cells. GM-CSF induces partially committed progenitor cells to divide and differentiate in the granulocyte-macrophage pathways…
Pharmacologic Class:
Leukocyte Growth Factor
Indications
Data Sources
- Drug label: DailyMed / FDA
- Clinical trials: ClinicalTrials.gov
- Patent data: FDA Orange Book
- Spending data: CMS Medicare
The information on this page is for informational purposes only and should not be used as a substitute for professional medical advice. Drug information is sourced from FDA, DailyMed, and other government databases. Adverse event data from FAERS does not establish causation. Always consult a healthcare professional for medical decisions.